Yes.
You can create a Dynamic Audience Segment to automatically filter out subscribers who don’t engage with your emails. For example, you might set up a segment for people who haven’t opened or clicked in the last 10 or 20 emails. Then, simply exclude that segment whenever you send a campaign.
How to set this up:
Go to Audiences > Create Segment.
Choose Dynamic Audience.
Select the condition: Has not opened OR clicked in the last [X] days.
Save it as “Inactive Subscribers.”
When creating a campaign, check Exclude Segment and pick “Inactive Subscribers.”
Why this matters:
Protects your deliverability (ISPs see you’re only mailing active users).
Improves campaign performance (higher open/click rates).
Prevents bothering people who aren’t interested.
Pro tip:
You don’t have to forget about these people completely. Add a Re-Engagement Automation just for them — e.g. “Still want to hear from us?” or a special offer. If they still don’t respond, then keep them excluded.